THE PROBIO TRIAL: MOLECULAR BIOMARKERS FOR ADVANCING PERSONALIZED TREATMENT DECISION IN PATIENTS WITH METASTATIC CASTRATION-RESISTANT PROSTATE CANCER

Abstract Background Multiple therapies exist for patients with metastatic castration-resistant prostate cancer (mCRPC).However, their improvement on progression-free survival (PFS) remains modest, potentially explained by tumor molecular heterogeneity.Several prognostic molecular biomarkers have been identified for mCRPC Safety Gloves that may have

Idiopathic pulmonary fibrosis (IPF), Antifungals a progressive fibrosing lung condition is a ther-apeutic medical challenge.The etiopathogenesis of IPF is complicated and hitherto not adequately understood.However, the concept, of late, is shifting from fibrosis as a result of inflammation to a mechanism of primarily dysregulated fibrogenesis.A cla

An increasing amount of evidence indicates that developmental programs are tightly regulated by the complex interplay between signaling pathways, as well as transcriptional and epigenetic processes.Here, we have uncovered coordination between transcriptional and morphogen cues to specify Merkel cells, poorly understood skin cells that mediate light